From a Newcastle perspective, his absence from the FA Cup game at the Etihad in particular is a major blow, although Eddie Howe has a ready-made replacement in Tino Livramento.

Livramento replaced Trippier from the bench in the win over Wolves, and scored Newcastle’s final goal in stoppage time as he broke down the right-hand side and dribbled into the 18-yard box before stabbing a low finish past Daniel Bentley.

Meanwhile, Newcastle will not be rushing into attempts to secure a replacement for sporting director Dan Ashworth, who has been placed on gardening leave after expressing a desire to join Manchester United.

This week’s announcement that Richard Hughes will be leaving a similar role at Bournemouth at the end of the season sparked speculation that he could have been lined up for a move to St James’ Park.

However, sources claim that is not the case, with the Newcastle hierarchy confident they can negotiate the summer transfer window without Ashworth’s long-term successor in place.

The Magpies operated without a sporting director in the immediate aftermath of their Saudi Arabia-backed takeover, and enjoyed considerable success in the transfer windows prior to Ashworth’s arrival.